Cell-Nanoparticle Interaction Analysis

Background

Nowadays, nanoparticles have been widely used in industry and medicine. Nanoparticles are an interesting research field. Compared with traditional materials, nanomaterials will change the properties of the bulk material due to their unique physical and chemical properties, such as small size characteristics, thereby bringing novel characteristics and making them spread in biology. It has significant advantages in sensation, cell imaging, and drug delivery.

Generally, the efficacy of nanoparticles in medicine depends to a large extent on the process of cell-nanoparticle interactions. Therefore, in order to evaluate the efficacy or toxicity of nanomedicine or materials, it is necessary to detailed study the process and extent of the interaction between nanoparticles and biological, especially with cells. These researches have very important scientific significance for the better use of nanomaterials in the field of biomedicine (for example, improving transport efficiency and reducing toxic side effects).

Fig 1. Example imaging of nanoparticles and their cellular localization using fluorescence microscopy (Ivask, A.; et al. 2017)

Services

Creative Proteomics has established a technology platform that can comprehensively analyze cell-nanoparticle interactions. The combination of these technologies can complete qualitative, quantitative, and high-resolution analysis. The services we provide include but are not limited to the following aspects.

• Visual methods

We provide microscope-based technologies such as fluorescence microscope, dark-field microscopy, electron microscopy, Raman microspectroscopy, etc., which can help customers identify nanoparticles at the cellular level, but those methods are time-consuming and have low throughput.

• Flow cytometry

Flow cytometry is an extension of fluorescence microscopy, which improves sample throughput while providing qualitative information.

• Quantitative methods

They are supplements to qualitative analysis methods and are essential for a comprehensive understanding of cell-nanoparticle interactions. We provide mass spectrometry-based technologies, such as atomic emission, optical emission mass spectrometry (AES and OES) and inductively coupled plasma mass spectroscopy (ICP-MS). Laser ablation ICP-MS and laser desorption/ionization mass spectrometry can quantitatively measure nanoparticles and their constituent elements in solution.

Customers can choose a certain technology according to the needs of the project, or contact us directly for consultation, and our expert team will provide you with a customized experimental program.

Applications

• Cell-nanoparticle interaction research
• Nanotoxicology research
• Nanomaterials and nanomedicine development and optimization
• Evaluation of Nanomedicine Efficacy

Highlights

• Combining qualitative and quantitative methods
• Improved throughput
• Able to handle low-abundance samples
• Highly sensitive laboratory equipment
• High resolution and high accuracy
• Experienced technical team

The study of cell-nanoparticle interaction is necessary for the development of new nanomaterials and the study of their efficacy. Creative Proteomics combines a large number of qualitative and quantitative methods to form a comprehensive technology platform. On this platform, our technicians can provide high-throughput, high-resolution, and economical services according to customer needs. We are honored to be your competent research assistant.